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KMID : 0854720090290020096
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Korean Journal of Asthma, Allergy and Clinical Immunology
2009 Volume.29 No. 2 p.96 ~ p.104
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Clinical Characteristics of Allergic Asthmatics with Normal Total Serum IgE Levels
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Choi In-Seon
Kim Ok-Ki
Jeong Seong-Hoon
Lee Woo-Jin
Lee Seong-Ji
Sin Hong-Joon
Han Eui-Ryoung
Jeong Ji-Min
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Abstract
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Background: Although allergic diseases occur through IgE-mediated reaction, about 20% of allergic asthmatics have normal total serum IgE levels.
Objective: To characterize the allergic asthmatics with normal total serum IgE levels.
Method: Medical records of 430 consecutive allergic asthmatics, who received the tests for both total IgE and allergen-specific IgE in the serum or on the skin, were reviewed. According to the total and specific IgE levels, the subjects were classified to 4 groups (I, increased/strong; II, normal/strong; III, increased/weak; IV, normal/weak).
Result: The Dermatophagoides farinae-specific IgE level in the serum was significantly related to the total serum IgE level (r=0.322, P＜0.001). The D. farinae-specific IgE levels were significantly lower in the group II than in the group I (3.27±0.14 vs. 1.83±0.30, P＜0.01) and the group IV than in the group III (0.79±0.05 vs. 0.44±0.13, P＜0.01). The results for D. pteronyssinus and sum of checked allergens were similar. The proportion of the patients sensitized to single allergen to total subjects was 7.5%/13.5%/33.0%/40.0% for I/II/III/IV groups (χ2=44.5, P＜0.001).
Conclusion: The allergic asthmatics with normal total serum IgE levels had lower allergen-specific IgE levels and a higher proportion of the patients sensitized to single allergen. The levels of total serum IgE may be determined by the degree of sensitization in allergic asthma.
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KEYWORD
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Allergen, Allergic asthma, Total IgE, Specific IgE, Skin test
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